Phenyltoloxamine

Preferred Label : Phenyltoloxamine;

NCIt synonyms : Antin; Histionex; Bristamin; N,N-Dimethyl-2-(alpha-phenyl-o-tolyloxy)ethylamine; N,N-Dimethyl-2-(2-(phenylmethyl)phenoxy)ethanamine;

NCIt definition : An ethanolamine derivative with antihistaminic property. Phenyltoloxamine blocks H1 histamine receptors, thereby inhibiting phospholipase A2 and production of endothelium-derived relaxing factor, nitric oxide. Subsequent lack of activation of guanylyl cyclase through nitric oxide results in decreased cyclic GMP levels, thereby inhibiting smooth muscle constriction of various tissues, decreasing capillary permeability and decreasing other histamine-activated allergic reactions.;

UNII : K65LB6598J;

InChIKey : IZRPKIZLIFYYKR-UHFFFAOYSA-N;

CAS number : 92-12-6;

Chemical formula : C17H21NO;

Details

Origin ID

C47669;

UMLS CUI

C0070709;

Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Phenyltoloxamine [ICD-11 Extension code]
- Phenyltoloxamine [LOINC component]
- Phenyltoloxamine (substance) [SNOMED CT concept]
- Product containing phenyltoloxamine (medicinal product) [SNOMED CT concept]
- phenyltoloxamine [Substance BNPC]
- phenyltoloxamine [MeSH concept]
- phenyltoloxamine [SNOMED Notion]
- phenyltoloxamine [MeSH Supplementary Concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
has_salt_form
- Phenyltoloxamine Citrate [NCIt concept]
- Phenyltoloxamine Hydrochloride [NCIt concept]
is_free_acid_or_base_form_of
- Phenyltoloxamine Citrate [NCIt concept]
- Phenyltoloxamine Hydrochloride [NCIt concept]

Keyword's position in hierarchy(ies) :

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