NCIt definition : A semi-synthetic ergot derivative and a dopamine agonist with antiparkinson property.
Pergolide mesylate binds to and activates dopamine receptor subtypes D1 and D2, resulting
in prolactin secretion inhibition, transient increase in serum concentration of growth
hormone, and decrease in serum concentration of luteinizing hormone. Direct stimulation
of postsynaptic dopamine receptors in the nigrostriatal system, may account for this
agent's antiparkinson activity.;