Preferred Label : Pentobarbital Sodium;
NCIt synonyms : Pental; Mebumal Sodium; Barpental; 2,4,6(1H,3H,5H)-Pyrimidinetrione, 5-Ethyl-5-(1-methylbutyl), Monosodium Salt; Barbituric Acid, 5-ethyl-5-(1-methylbutyl)-,Sodium Salt;
NCIt definition : The sodium salt of pentobarbital, a short-acting barbituric acid derivative with central
nervous system (CNS) depressant property. Pentobarbital sodium binds to the gamma-aminobutyric
acid (GABA)-A subtype receptor, resulting in modulation of chloride transport through
receptor channels and potentiation of GABA-induced increases in chloride conductance.
This enhances postsynaptic responses to the inhibitory actions of GABA and causes
CNS depression. In addition, this agent inhibits glutamate induced nerve depolarization
and depresses voltage-activated calcium currents.;
UNII : NJJ0475N0S;
InChIKey : QGMRQYFBGABWDR-UHFFFAOYSA-M;
CAS number : 57-33-0;
Drug name : Nembutal;
Chemical formula : C11H17N2O3.Na;
NSC code : 10816;
Origin ID : C47662;
UMLS CUI : C0700349;
Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to NTBT
- concept_is_in_subset
- has_free_acid_or_base_form
- is_salt_form_of
