Pentaerythritol Tetranitrate

Preferred Label : Pentaerythritol Tetranitrate;

NCIt synonyms : Pentafin; Vasolat; 1,3-Propanediol, 2,2-bis((nitrooxy)methyl)-, Dinitrate(ester); 1,3-Dinitrato-2,2-bis(nitratomethyl)propane;

NCIt definition : The lipid soluble polyol ester of nitric acid belonging to the family of nitrovasodilators that exhibit vasodilatory property. Pentaerythritol tetranitrate releases free nitric oxide (NO) after denitration reaction, which triggers NO-dependent signaling transduction involving soluble guanylate cyclase (sGC). NO binds reversibly to the ferrous-heme center of sGC, thereby causes conformational change and activates the enzyme. Activation results in increasing cellular levels of cyclic guanosine monophosphate (cGMP) within vascular smooth muscle, which results in vasodilation mediated by cGMP-dependent protein kinases. Furthermore, this agent causes arterial and venous bed dilation in a dose-dependent manner.;

UNII : 10L39TRG1Z;

InChIKey : TZRXHJWUDPFEEY-UHFFFAOYSA-N;

CAS number : 78-11-5;

Drug name : Peritrate;

Chemical formula : C5H8N4O12;

ChEBI ID : CHEBI:25879;

Details

Origin ID

C47660;

UMLS CUI

C0030858;

Automatic exact mappings (from CISMeF team)
- Pentaerythritol tetranitrate [ICHI extension code]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Pentaerithrityl tetranitrate (substance) [SNOMED CT concept]
- Pentaerythritol tetranitrate [ICD-11 Extension code]
- Pentaerythrityl tetranitrate [ICD-11 Extension code]
- Product containing pentaerithrityl tetranitrate (medicinal product) [SNOMED CT concept]
- pentaerithrityl tetranitrate [ATC Code]
- pentaerithrityl tetranitrate [Substance BNPC]
- pentaerythritol tetranitrate [SNOMED Notion]
- pentaerythritol tetranitrate [MeSH Descriptor]
- pentaerythritol tetranitrate [MeSH concept]
Validated automatic mappings to BTNT
- pentaerithrityl [ATC Code]
- pentaerithrityl tetranitrate [ATC Code]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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