NCIt definition : An oxazolidine compound with central nervous system (CNS) stimulant property. Although
pemoline has pharmacological activity similar to other CNS stimulants, the exact mechanism
and site of action are unknown. This agent has minimal sympathomimetic properties,
but animal studies indicate it may work through dopaminergic mechanisms. Pemoline
has been withdrawn from the U.S. market because of the agent's association with life
threatening hepatic failure.;