Preferred Label : Nesiritide;
NCIt synonyms : Human Brain Natriuretic Factor-32; Natriuretic factor-32; Natriuretic Peptide Type-B; 1,2-Dithia-5,8,11,14,17,20,23,26,29,32,35,38,41,44,47,50-hexadecaazacyclotripentacontane,
Cyclic Peptide Derivative; L-Histidine, L-seryl-L-prolyl-L-lysyl-L-methionyl-L-valyl-L-glutaminylglycyl-L-serylglycyl-L-cysteinyl-L-phenylalanylglycyl-L-arginyl-L-lysyl-L-methionyl-L-alpha-aspartyl-L-arginyl-L-isoleucyl-L-seryl-L-seryl-L-seryl-L-serylglycyl-L-leucylglycyl-L-cysteinyl-L-lysyl-L-valyl-L-leucyl-L-arginyl-L-arginyl-,
Cyclic (10-26)-disulfide;
NCIt definition : A recombinant version of the cardiac neurohormone, human B-type natriuretic peptide
(hBNP) produced by the ventricular myocardium. Nesiritide binds to natriuretic peptide
receptors on vascular smooth muscle and endothelial cells, through which it triggers
guanylate cyclase dependent signal transduction resulting in increase of intracellular
concentrations of cGMP. This leads to smooth muscle cell relaxation causing arterial
and venous dilatation.;
UNII : P7WI8UL647;
CAS number : 124584-08-3;
Chemical formula : C143H244N50O42S4;
Origin ID : C47636;
UMLS CUI : C0054015;
Automatic exact mappings (from CISMeF team)
- See also inter- (CISMeF)
- Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to BTNT
- concept_is_in_subset
- has_salt_form
- is_free_acid_or_base_form_of
