" /> Naftifine Hydrochloride - CISMeF





Preferred Label : Naftifine Hydrochloride;

NCIt synonyms : (E)-N-methyl-N-(1-naphthylmethyl)-3-phenyl-2-propen-1-amine-hydrochloride;

NCIt definition : The hydrochloride salt form of naftifine, an allylamine derivate with synthetic broad-spectrum antifungal activity. Although the exact mechanism through which naftifine hydrochloride exerts its effect is unknown, it appears to selectively inhibit the enzyme squalene 2,3-epoxidase, thereby inhibiting the biosynthesis of sterol. This results in a decreased amount of sterols, especially ergosterol which is the primary fungal membrane sterol, and a corresponding accumulation of squalene in fungal cells. Naftifine hydrochloride can be fungicidal as well as fungistatic to yeasts depending on the concentration and the organisms involved.;

UNII : 25UR9N9041;

InChIKey : OLUNPKFOFGZHRT-YGCVIUNWSA-N;

CAS number : 65473-14-5;

Drug name : Naftin;

Molecule name : SN 105843;

Chemical formula : C21H21N.HCl;

Détails


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28/07/2025


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