NCIt definition : The hydrochloride salt form of naftifine, an allylamine derivate with synthetic broad-spectrum
antifungal activity. Although the exact mechanism through which naftifine hydrochloride
exerts its effect is unknown, it appears to selectively inhibit the enzyme squalene
2,3-epoxidase, thereby inhibiting the biosynthesis of sterol. This results in a decreased
amount of sterols, especially ergosterol which is the primary fungal membrane sterol,
and a corresponding accumulation of squalene in fungal cells. Naftifine hydrochloride
can be fungicidal as well as fungistatic to yeasts depending on the concentration
and the organisms involved.;