NCIt definition : An orally administered vasodilator with hair growth stimulatory and antihypertensive
effects. Minoxidil is converted into its active metabolite minoxidil sulphate by sulphotransferase
enzymes. Minoxidil sulphate exerts its antihypertensive effect by opening of plasma
membrane adenosine triphosphate (ATP)-sensitive potassium channels (KATP channels),
thereby directly and rapidly relaxing arteriolar smooth muscle and subsequent reduction
of elevated systolic and diastolic blood pressure by decreasing peripheral vascular
resistance. This agent's hair growth stimulatory effect may be mediated through its
vasodilatory activity, thereby increasing cutaneous blood flow, or due to its direct
stimulatory effect on hair follicle cells and forcing them from their resting phase
into their active growth phase.;