Preferred Label : Minocycline Hydrochloride;
NCIt synonyms : Minomycin; 4,7-Bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-2-naphthacenecarboxamide
Monohydrochloride; Tri-minocycline; Minomax;
NCIt definition : The hydrochloride salt of minocycline, a broad spectrum long-acting derivative of
the antibiotic tetracycline, with antibacterial and anti-inflammatory activities.
Minocycline binds to the bacterial 30S ribosomal subunit and interferes with the binding
of tRNA to the ribosomal complex, thereby inhibiting protein translation in bacteria.
In addition, minocycline inhibits the inflammatory enzyme 5-lipoxygenase (5LOX) and
may impede T cell-microglia interactions; both activities may contribute to minocycline's
neuroprotective effects. 5LOX catalyzes the synthesis of inflammatory mediators such
as prostaglandins and leukotrienes.;
UNII : 0020414E5U;
InChIKey : GLMUAFMGXXHGLU-VQAITOIOSA-N;
CAS number : 13614-98-7;
Drug name : Dynacin; Minocin; Vectrin;
Chemical formula : C23H27N3O7.HCl;
NSC code : 141993;
ChEBI ID : CHEBI:50697;
Origin ID : C47622;
UMLS CUI : C0026186;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
- Validated automatic mappings to NTBT
- concept_is_in_subset
- has_free_acid_or_base_form
- is_salt_form_of
