Methyldopate Hydrochloride

Preferred Label : Methyldopate Hydrochloride;

NCIt synonyms : Aldomet Ester Hydrochloride; Methyldopa Ethyl Ester Hydrochloride; L-3-(3,4-Dihydroxyphenyl)-2-methylalanine Ethyl Ester Hydrochloride; L-Tyrosine, 3-hydroxy-alpha-methyl-, Ethyl Ester, Hydrochloride;

NCIt definition : The hydrochloride salt form of methyldopa, a phenylalanine derivate and aromatic amino acid decarboxylase inhibitor with antihypertensive activity. Methyldopa is a prodrug and is metabolized in the central nervous system. The antihypertensive action of methyldopa seems to be attributable to its conversion into alpha-methylnorepinephrine, which is a potent alpha-2 adrenergic agonist that binds to and stimulates potent central inhibitory alpha-2 adrenergic receptors. This results in a decrease in sympathetic outflow and decreased blood pressure.;

UNII : 7PX435DN5A;

InChIKey : QSRVZCCJDKYRRF-YDALLXLXSA-N;

CAS number : 2508-79-4;

Chemical formula : C12H17NO4.HCl;

Details

Origin ID

C47617;

UMLS CUI

C0304527;

Currated CISMeF NLP mapping
- Methyldopate hydrochloride (substance) [SNOMED CT concept]
- methyldopate hydrochloride [SNOMED Notion]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Methyldopate hydrochloride (substance) [SNOMED CT concept]
- methyldopate hydrochloride [SNOMED Notion]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
has_free_acid_or_base_form
- Methyldopate [NCIt concept]
is_salt_form_of
- Methyldopate [NCIt concept]

Keyword's position in hierarchy(ies) :

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