Methyldopa - CISMeF

Preferred Label : Methyldopa;

NCIt synonyms : Levo-3-(3,4-Dihydroxyphenyl)-2-methylalanine; L-2-Amino-2-methyl-3-(3,4-dihydroxyphenyl)propionic Acid; 3-Hydroxy-alpha-methyl-L-tyrosine;

NCIt definition : A phenylalanine derivative and an aromatic amino acid decarboxylase inhibitor with antihypertensive activity. Methyldopa is a prodrug and is metabolized in the central nervous system. The antihypertensive action of methyldopa seems to be attributable to its conversion into alpha-methylnorepinephrine, which is a potent alpha-2 adrenergic agonist that binds to and stimulates potent central inhibitory alpha-2 adrenergic receptors. This results in a decrease in sympathetic outflow and decreased blood pressure.;

UNII : 56LH93261Y;

InChIKey : YKFCISHFRZHKHY-NGQGLHOPSA-N;

CAS number : 41372-08-1;

Drug name : Aldomet; Dopamet; Amodopa;

Chemical formula : 2C10H13NO4.3H2O;

NSC code : 169916;

ChEBI ID : CHEBI:61058;

Codes from synonyms : 32050;

Details

Origin ID

C47616;

UMLS CUI

C0025741;

See also inter- (CISMeF)
- Methyldopa adverse reaction (disorder) [SNOMED CT concept]
- Product containing methyldopa (medicinal product) [SNOMED CT concept]
- methyldopa [ATC Code]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Methyldopa [ICD-11 Extension code]
- Methyldopa [LOINC component]
- Methyldopa (substance) [SNOMED CT concept]
- Product containing methyldopa (medicinal product) [SNOMED CT concept]
- methyldopa [MeSH concept]
- methyldopa [MeSH Descriptor]
- methyldopa [SNOMED Notion]
- methyldopa (levorotatory) [ATC Code]
Validated automatic mappings to BTNT
- methyldopa (levorotatory) [ATC Code]
- methyldopa (racemic) [ATC Code]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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