High Grade Vulvar Squamous Intraepithelial Lesion

Preferred Label : High Grade Vulvar Squamous Intraepithelial Lesion;

NCIt synonyms : VIN Grade 2; Intraepithelial Neoplasia of Vulva Grade 2; Vulvar Intraepithelial Neoplasia Grade 2; Vulva Intraepithelial Neoplasia Grade 2; Grade 2 VIN; Grade II VIN; Grade II Vulvar Intraepithelial Neoplasia; Intraepithelial Neoplasia of the Vulva Grade 2; Vulva Intraepithelial Neoplasia Grade 3; VIN, Usual Type; Vulvar High-Grade Squamous Intraepithelial Lesion; Vulvar Intraepithelial Neoplasia 2 of Usual Type; Vulvar Moderate Squamous Dysplasia; VIN 3 of Usual Type; Grade 3 VIN; Vulvar Intraepithelial Neoplasia Grade 3; Vulvar Severe Squamous Dysplasia; VIN 2; VIN 3; Vulvar Intraepithelial Neoplasia 3 of Usual Type; Vulvar Intraepithelial Neoplasia, Usual Type; Vulvar Bowenoid Dysplasia; Vulvar High Grade Squamous Intraepithelial Lesion; VIN 2 of Usual Type; Vulvar Bowen Disease; Grade 2 Vulvar Intraepithelial Neoplasia; Vulvar HSIL;

NCIt definition : An intraepithelial lesion of the vulvar squamous epithelium associated with HPV infection. It is characterized by loss of maturation, nuclear hyperchromasia, high nuclear:cytoplasmic ratios, cytological and architectural atypia, and mitoses. Two morphological patterns have been described: basaloid (undifferentiated) and warty (condylomatous, bowenoid). It carries a significant but relatively low risk of progression to squamous cell carcinoma if untreated. (WHO 2020);

Neoplastic status : Undetermined;

Details

Origin ID

C4761;

UMLS CUI

C0495107;

Automatic exact mappings (from CISMeF team)
- vulvar diseases [MeSH Descriptor]
Disease excludes abnormal cell
- Neoplastic Glandular Cell [NCIt concept]
- Neoplastic Smooth Muscle Cell [NCIt concept]
Disease may have findings
- Macular Lesion [NCIt concept]
- Papular Lesion [NCIt concept]
- Pruritus [NCIt concept]
Has associated anatomic sites
- Female Reproductive System [NCIt concept]
- Genitourinary System [NCIt concept]
- Reproductive System [NCIt concept]
- Vulva [NCIt concept]
Semantic type(s)
- Neoplastic Process [UMLS semantic type]
UMLS correspondences (same concept)
- Moderate vulvar dysplasia [ICD-10 Sub-category]
- Moderate vulvar dysplasia [ICD-10 Sub-category (who)]
- Vulval intraepithelial neoplasia grade 2 (disorder) [SNOMED CT concept]
- Vulval intraepithelial neoplasia grade II [MedDRA LLT]
- Vulvar intraepithelial neoplasia II [VIN II] [ICD-9 code]
disease_excludes_finding
- Invasive Lesion [NCIt concept]
- Mixed Neoplastic Glandular and Squamous Cell Population [NCIt concept]
disease_has_abnormal_cell
- Dysplastic Squamous Cell [NCIt concept]
- Neoplastic Cell [NCIt concept]
- Neoplastic Epithelial Cell [NCIt concept]
- Neoplastic Squamous Cell [NCIt concept]
disease_has_associated_disease
- Human Papillomavirus Infection [NCIt concept]
disease_has_finding
- Dysplasia [NCIt concept]
- Epithelial Component Present [NCIt concept]
- Human Papillomavirus Positive [NCIt concept]
disease_has_grade
- High Grade [NCIt concept]
disease_has_normal_cell_origin
- Epithelial Cell [NCIt concept]
- Squamous Cell [NCIt concept]
disease_has_normal_tissue_origin
- Epithelial Tissue [NCIt concept]
- Squamous Epithelium [NCIt concept]
disease_has_primary_anatomic_site
- Female Reproductive System [NCIt concept]
- Vulva [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients