NCIt definition : An anthranilic acid and non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory,
antipyretic and analgesic activities. Mefenamic acid inhibits the activity of the
enzymes cyclo-oxygenase I and II, resulting in a decreased formation of precursors
of prostaglandins and thromboxanes. The resulting decrease in prostaglandin synthesis,
by prostaglandin synthase, is responsible for the therapeutic effects of mefenamic
acid. Mefenamic acid also causes a decrease in the formation of thromboxane A2 synthesis,
by thromboxane synthase, thereby inhibiting platelet aggregation.;