" /> Mafenide Acetate - CISMeF





Preferred Label : Mafenide Acetate;

NCIt synonyms : alpha-Amino-p-toluenesulfonamide Monoacetate; Sulfamilon; 4-(Aminomethyl)benzenesulfonamide Monoacetate;

NCIt definition : The acetate salt form of mafenide, a synthetic sulfonamide analog of para-aminobenzoic acid (PABA) with topical anti-infective activity. Mafenide acetate competes with PABA for the bacterial enzyme dihydropteroate synthase, thereby preventing the incorporation of PABA into dihydrofolic acid, thereby interferes with normal folic acid metabolism. As a result, de novo synthesis of pyrimidines, which requires folate metabolites, is impeded and subsequently DNA synthesis is affected. Mafenide acetate is bacteriostatic against many gram-negative and gram-positive organisms, including Pseudomonas aeruginosa and certain strains of anaerobes.;

UNII : RQ6LP6Z0WY;

InChIKey : UILOTUUZKGTYFQ-UHFFFAOYSA-N;

CAS number : 13009-99-9;

Drug name : Sulfamylon;

Chemical formula : C7H10N2O2S.C2H4O2;

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28/05/2025


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