NCIt definition : The hydrochloride salt form of lomefloxacin, a synthetic broad-spectrum fluoroquinolone
with antibacterial activity. Lomefloxacin hydrochloride inhibits DNA gyrase, a type
II topoisomerase involved in the induction or relaxation of supercoiling during DNA
replication. This inhibition leads to a decrease in DNA synthesis during bacterial
replication, resulting in cell growth inhibition and eventually cell lysis.;