Levonordefrin - CISMeF

Preferred Label : Levonordefrin;

NCIt synonyms : Neo-Cobefrin; (-)-alpha-(1-Aminoethyl)-3,4-dihydroxybenzyl Alcohol; 1,2-Benzenediol, 4-(2-amino-1-hydroxypropyl)-,(R-(R*,S*))-;

NCIt definition : The levoisomer of nordefrin, a synthetic catecholamine and norepinephrine derivative with sympathomimetic and antihypertensive effects. Levonordefrin's antihypertensive effect is exerted through activation of alpha 2-adrenergic receptors in the cardiovascular control center of the CNS thereby suppressing the sympathetic output from the brain and subsequently lowering blood pressure. Levonordefrin binds to and activates peripheral alpha 2- adrenergic receptors, thereby causing vasoconstriction.;

UNII : V008L6478D;

InChIKey : GEFQWZLICWMTKF-CDUCUWFYSA-N;

CAS number : 829-74-3; 18829-78-2;

Chemical formula : C9H13NO3;

Details

Origin ID

C47584;

UMLS CUI

C0520472;

Automatic exact mappings (from CISMeF team)
- Levonordefrin [ICHI extension code]
- nordefrin [MeSH Descriptor]
Currated CISMeF NLP mapping
- Corbadrine [ICD-11 Extension code]
- Corbadrine (substance) [SNOMED CT concept]
- Levonordefrin [ICD-11 Extension code]
- Neo-Cobefrin [MeSH concept]
- corbadrine [MeSH concept]
- levonordefrin [SNOMED Notion]
See also inter- (CISMeF)
- Product containing corbadrine (medicinal product) [SNOMED CT concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Corbadrine (substance) [SNOMED CT concept]
- Levonordefrin [ICD-11 Extension code]
- Product containing corbadrine (medicinal product) [SNOMED CT concept]
- corbadrine [MeSH concept]
- levonordefrin [SNOMED Notion]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
has_salt_form
- Levonordefrin Hydrochloride [NCIt concept]
is_free_acid_or_base_form_of
- Levonordefrin Hydrochloride [NCIt concept]

Keyword's position in hierarchy(ies) :

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