NCIt definition : The levoisomer of nordefrin, a synthetic catecholamine and norepinephrine derivative
with sympathomimetic and antihypertensive effects. Levonordefrin's antihypertensive
effect is exerted through activation of alpha 2-adrenergic receptors in the cardiovascular
control center of the CNS thereby suppressing the sympathetic output from the brain
and subsequently lowering blood pressure. Levonordefrin binds to and activates peripheral
alpha 2- adrenergic receptors, thereby causing vasoconstriction.;