Levetiracetam - CISMeF

Preferred Label : Levetiracetam;

NCIt synonyms : (S)-alpha-Ethyl-2-oxo-1-pyrrolidineacetamide; 1-Pyrrolidineacetamide, Alpha-ethyl-2-oxo-,(S)-;

NCIt related terms : Keppra;

NCIt definition : A pyrrolidine with antiepileptic activity. The exact mechanism through which levetiracetam exerts its effects is unknown but does not involve inhibitory and excitatory neurotransmitter activity. Stereoselective binding of levetiracetam was confined to synaptic plasma membranes in the central nervous system with no binding occurring in peripheral tissue. Levetiracetam inhibits burst firing without affecting normal neuronal excitability, which suggests that it may selectively prevent hyper-synchronization of epileptiform burst firing and propagation of seizure activity.;

Alternative definition : NCI-GLOSS: A drug used to treat seizures (involuntary muscle movements) caused by epilepsy (a group of brain disorders). Keppra is being studied in the treatment of seizures in patients with cancer that has spread to the brain. It is a type of anticonvulsant.;

UNII : 44YRR34555;

InChIKey : HPHUVLMMVZITSG-LURJTMIESA-N;

CAS number : 102767-28-2;

Drug name : Keppra;

Chemical formula : C8H14N2O2;

ChEBI ID : CHEBI:6437;

Codes from synonyms : CDR0000556426; CDR0000533417;

Details

Origin ID

C47581;

UMLS CUI

C0377265;

Automatic exact mappings (from CISMeF team)
- levETIRAcetam:MCnc:Pt:Ser/Plas:Qn: [LOINC code]
Currated CISMeF NLP mapping
- Levetiracetam [MeSH Descriptor]
- Levetiracetam [ICD-11 Extension code]
- Levetiracetam [SMS substance]
- Levetiracetam (substance) [SNOMED CT concept]
- levETIRAcetam [LOINC component]
- levetiracetam [Substance BNPC]
- levetiracetam [International Nonproprietary Name]
- levetiracetam [MeSH concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Levetiracetam [MeSH Descriptor]
- Levetiracetam (substance) [SNOMED CT concept]
- Product containing levetiracetam (medicinal product) [SNOMED CT concept]
- levETIRAcetam [LOINC component]
- levetiracetam [ATC Code]
- levetiracetam [International Nonproprietary Name]
- levetiracetam [Substance BNPC]
- levetiracetam [MeSH concept]
Validated automatic mappings to BTNT
- levetiracetam [ATC Code]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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