Preferred Label : Levalbuterol Hydrochloride;
NCIt synonyms : (-)-Salbutamol Hydrochloride; 1,3-Benzenedimethanol, alpha1-(((1,1-dimethylethyl)amino)methyl)-4-hydroxy-, Hydrochloride,(alpha1R)-;
NCIt definition : The hydrochloride salt form of levalbuterol, a relatively selective sympathomimetic
beta-2 adrenergic receptor agonist with bronchodilator activity. Levalbuterol hydrochloride
binds to beta-2 adrenergic receptors in bronchial smooth muscle and activates intracellular
adenyl cyclase, thereby increasing the production of cyclic-3', 5'-adenosine monophosphate
(cAMP). Increased cAMP levels lead to the activation of protein kinase A, which inhibits
the phosphorylation of myosin and lowers intracellular ionic calcium concentrations,
resulting in relaxation of bronchial smooth muscles. The increased cyclic AMP concentrations
also inhibit the release of inflammatory mediators from mast cells.;
UNII : WDQ1526QJM;
InChIKey : OWNWYCOLFIFTLK-YDALLXLXSA-N;
CAS number : 50293-90-8;
Drug name : Xopenex;
Chemical formula : C13H21NO3.HCl;
Origin ID : C47580;
UMLS CUI : C0772502;
Automatic exact mappings (from CISMeF team)
- Currated CISMeF NLP mapping
- See also inter- (CISMeF)
- Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to NTBT
- concept_is_in_subset
- has_free_acid_or_base_form
- is_salt_form_of
