Isocarboxazid - CISMeF

Preferred Label : Isocarboxazid;

NCIt synonyms : 3-Isoxazolecarboxylic Acid, 5-methyl-, 2-(phenylmethyl)hydrazide;

NCIt definition : A hydralazine and monoamine oxidase (MAO) inhibitor with antidepressant activity. Isocarboxazid blocks the breakdown (oxidative deamination) of biogenic amines by inhibiting MAO, thereby increasing the concentrations of norepinephrine and 5-hydroxytrytamine (5-HT) at central aminergic receptors. These neurotransmitters are involved in sustaining mood and emotions. The down-regulation of central beta-adrenergic and serotonergic receptors by chronic inhibition of MAO may also contribute to the antidepressant effects seen by isocarboxazid. (NCI05);

UNII : 34237V843T;

InChIKey : XKFPYPQQHFEXRZ-UHFFFAOYSA-N;

CAS number : 59-63-2;

Drug name : Marplan;

Molecule name : Ro 5-0831;

Chemical formula : C12H13N3O2;

NSC code : 169893;

Details

Origin ID

C47573;

UMLS CUI

C0022154;

Automatic exact mappings (from CISMeF team)
- Isocarboxazid [ICHI extension code]
See also inter- (CISMeF)
- Product containing isocarboxazid (medicinal product) [SNOMED CT concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Isocarboxazid [ICD-11 Extension code]
- Isocarboxazid [LOINC component]
- Isocarboxazid (substance) [SNOMED CT concept]
- Product containing isocarboxazid (medicinal product) [SNOMED CT concept]
- isocarboxazid [ATC Code]
- isocarboxazid [Substance BNPC]
- isocarboxazid [MeSH concept]
- isocarboxazid [MeSH Descriptor]
- isocarboxazid [SNOMED Notion]
Validated automatic mappings to BTNT
- isocarboxazid [ATC Code]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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