NCIt definition : The succinate salt form of frovatriptan, a synthetic triptan with serotonin (5-HT)
receptor agonist activity. Frovatriptan succinate binds selectively and with high
affinity to 5-HT 1B and presynaptic 5-HT 1D receptors in the extracerebral and intracranial
arteries. This leads to an inhibition of serotonin activity and results in vasoconstriction
of the painfully dilated blood vessels during migraine attack. Frovatriptan succinate
is indicated for the acute treatment of migraine. (NCI05);