" /> Fosfomycin Tromethamine - CISMeF





Preferred Label : Fosfomycin Tromethamine;

NCIt synonyms : Fosfomycin compound with Trometamol; Fosfomycin Trometamol Salt; (1R,2S)-(1,2-Epoxypropyl)phosphonic Acid, compound with 2-Amino-2-(hydroxymethyl)-1,3-propanediol(1:1);

NCIt definition : The tromethamine salt form of fosfomycin, a synthetic broad-spectrum antibiotic. Fosfomycin tromethamine binds to and inactivates the enzyme enolpyruvyl transferase. This leads to an irreversible blockage of the condensation of uridine diphosphate-N-acetylglucosamine with p-enolpyruvate, which is one of the first steps of bacterial cell wall synthesis, thereby eventually causing cell lysis. In addition, fosfomycin tromethamine reduces the adherence of bacteria to uroepithelial cells. (NCI05);

UNII : 7FXW6U30GY;

InChIKey : QZJIMDIBFFHQDW-LMLSDSMGSA-N;

CAS number : 78964-85-9;

Drug name : Monurol;

Chemical formula : C4H11NO3.C3H7O4P;

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02/11/2025


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