Flumazenil - CISMeF

Preferred Label : Flumazenil;

NCIt synonyms : Anexate; Lanexat; 4H-Imidazo(1,5-a)(1,4)benzodiazepine-3-carboxylic Acid, 8-fluoro-5,6-dihydro-5-methyl-6-oxo-, Ethyl Ester;

NCIt definition : An imidazo-benzodiazepine derivative, effective in reversing benzodiazepine-induced activities. Flumazenil antagonizes the benzodiazepine binding site of the gamma-aminobutyric acid (GABA)/benzodiazepine receptor complex in the central nervous system (CNS), thereby preventing the chloride channel opening events and inhibiting neuronal hyperpolarization. As a result, flumazenil reverses benzodiazepine-induced effects including sedation, psychomotor deficits, amnesia, and hypoventilation in a dose-dependent manner.;

UNII : 40P7XK9392;

InChIKey : OFBIFZUFASYYRE-UHFFFAOYSA-N;

CAS number : 78755-81-4;

Drug name : Romazicon;

Molecule name : Ro 151788;

Chemical formula : C15H14FN3O3;

ChEBI ID : CHEBI:5103;

Details

Origin ID

C47534;

UMLS CUI

C0016293;

Automatic exact mappings (from CISMeF team)
- Anexate [MeSH concept]
- Lanexat [MeSH concept]
- romazicon [MeSH concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Flumazenil (substance) [SNOMED CT concept]
- Product containing flumazenil (medicinal product) [SNOMED CT concept]
- flumazenil [ATC Code]
- flumazenil [MeSH concept]
- flumazenil [MeSH Descriptor]
- flumazenil [SNOMED Notion]
Validated automatic mappings to BTNT
- flumazenil [ATC Code]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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