NCIt definition : A propanediol compound with anticonvulsant and antiepileptic properties. Although
the exact mechanism of action is unknown, Felbamate may be an antagonist at the strychnine-insensitive
glycine-recognition site of the N-methyl-D-aspartate (NMDA) receptor-ionophore complex,
thereby blocking the effects of the excitatory amino acids, suppressing neuronal firing,
and preventing seizure activity. Felbamate also has weak inhibitory effects on gamma-aminobutyric
acid (GABA) receptor binding sites which may contribute to its inhibitory effect on
neuronal excitatory.;