" /> Ezetimibe - CISMeF





Preferred Label : Ezetimibe;

NCIt synonyms : Ezedoc; 1-(4-fluorophenyl)-3(R)-[3-(4-fluorophenyl)-3(S)-hydroxypropyl]-4(S)-(4-hydroxyphenyl)-2-azetidinone;

NCIt definition : An azetidinone derivative and a cholesterol absorption inhibitor with lipid-lowering activity. Ezetimibe appears to interact physically with cholesterol transporters at the brush border of the small intestine and inhibits the intestinal absorption of cholesterol and related phytosterols. As a result, ezetimibe causes a decrease in the level of blood cholesterol or an increase in the clearance of cholesterol from the bloodstream. Overall, the following effects observed are a reduction of hepatic cholesterol stores and a reduction of total cholesterol, LDL cholesterol, and other triglycerides in the blood.;

Alternative definition : ACC/AHA: A cholesterol absorption inhibitor with lipid-lowering activity;

UNII : EOR26LQQ24;

InChIKey : OLNTVTPDXPETLC-XPWALMASSA-N;

CAS number : 163222-33-1;

Drug name : Zetia;

Chemical formula : C24H21F2NO3;

ChEBI ID : CHEBI:49040;

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08/05/2025


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