Preferred Label : Epinastine Hydrochloride;
NCIt synonyms : Alesion; Elestat; 9,13b-Dihydro-1H-dibenz(c,f)imidazo(1,5-a)azepin-3-amine Hydrochloride;
NCIt definition : An histamine H1 receptor antagonist without sedative activity. Epinastine hydrochloride
blocks the histamine H1 receptor and inhibits the release of histamine from mast cells.
This prevents the typical allergic symptoms that are caused by histamine activity
on capillaries, skin, mucous membranes, and on gastrointestinal and bronchial smooth
muscles. Typical histamine activities include vasodilation, bronchoconstriction, increased
vascular permeability, pain, itching, and spasmodic contractions of gastrointestinal
smooth muscles. Epinastine also has affinity for the histamine H2, 5-HT2, and the
alpha-1, alpha-2 adrenergic receptors.;
UNII : GFM415S5XL;
InChIKey : VKXSGUIOOQPGAF-UHFFFAOYSA-N;
CAS number : 108929-04-0;
Chemical formula : C16H15N3.HCl;
ChEBI ID : CHEBI:51037;
Origin ID : C47512;
UMLS CUI : C0772294;
Semantic type(s)
- Validated automatic mappings to NTBT
- concept_is_in_subset
- has_free_acid_or_base_form
- is_salt_form_of
