Emtricitabine - CISMeF

Preferred Label : Emtricitabine;

NCIt synonyms : FTC; 2(1H)-Pyrimidinone, 4-amino-5-fluoro-1-(2-(hydroxymethyl)-1,3-oxathiolan-5-yl)-,(2R-cis)-; (-)-2'-Deoxy-5-fluoro-3'-thiacytidine; dOTFC;

NCIt definition : A synthetic fluoro derivative of thiacytidine with potent antiviral activity. Emtricitabine is phosphorylated to form emtricitabine 5'-triphosphate within the cell. This metabolite inhibits the activity of human immunodeficiency virus (HIV) reverse transcriptase both by competing with the natural substrate deoxycytidine 5'-triphosphate and by incorporation into viral DNA causing a termination of DNA chain elongation (due to the lack of the essential 3'-OH group).;

UNII : G70B4ETF4S;

InChIKey : XQSPYNMVSIKCOC-NTSWFWBYSA-N;

CAS number : 143491-57-0;

Drug name : Emtriva; Coviracil;

Molecule name : BW-524W91;

Chemical formula : C8H10FN3O3S;

ChEBI ID : CHEBI:31536;

Details

Origin ID

C47509;

UMLS CUI

C0909839;

CISMeF manual mappings
- Emtricitabine [MeSH Descriptor]
See also inter- (CISMeF)
- 2'-deoxy-5-fluoro-3'-thiacytidine [MeSH concept]
- 2'-deoxy-5-fluoro-3'-thiacytidine [MeSH Supplementary Concept]
- Product containing emtricitabine (medicinal product) [SNOMED CT concept]
Semantic type(s)
- Nucleic Acid, Nucleoside, or Nucleotide [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Emtricitabine [MeSH Descriptor]
- Emtricitabine [LOINC component]
- Emtricitabine (substance) [SNOMED CT concept]
- Product containing emtricitabine (medicinal product) [SNOMED CT concept]
- emtricitabine [ATC Code]
- emtricitabine [MeSH concept]
Validated automatic mappings to BTNT
- emtricitabine [ATC Code]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt COVID-19 Agent Terminology [NCIt concept]
- NCIt COVID-19 Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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