NCIt definition : A peripheral and central respiratory stimulant with a brief duration of action. Doxapram
hydrochloride stimulates respiration by an action on chemoreceptors in the carotid
arteries and, at increased dosage, stimulates central respiratory centers in the medulla
as well as other parts of the brain and spinal cord. This results in an increased
tidal volume and a slightly increased respiratory rate. Doxapram hydrochloride may
also improve cardiac output probably due to an increased release of catecholamines.
This respiratory stimulant is used in postanesthesia respiratory depression.;