Dofetilide - CISMeF

Preferred Label : Dofetilide;

NCIt synonyms : Methanesulfonamide, N-(4-(2-(methyl(2-(4-((methylsulfonyl)amino)phenoxy)ethyl)amino)ethyl)phenyl)-; beta-((p-Methanesulfonamidophenethyl)methylamino)methanesulfono-p-phenetidide;

NCIt definition : A sulfonamide class III antiarrhythmic agent and potassium channel blocker. Dofetilide selectively blocks cardiac ion channels of the rapid component of the delayed rectifier potassium current Ikr. This antiarrhythmic agent prolongs cardiac action potential duration and effective refractory period due to delayed repolarization without affecting conduction velocity. This results in a normal sinus rhythm. Dofetilide is used in the treatment of atrial fibrillation and flutter.;

UNII : R4Z9X1N2ND;

InChIKey : IXTMWRCNAAVVAI-UHFFFAOYSA-N;

CAS number : 115256-11-6;

Drug name : Tikosyn;

Chemical formula : C19H27N3O5S2;

ChEBI ID : CHEBI:4681;

Details

Origin ID

C47499;

UMLS CUI

C0114771;

Automatic exact mappings (from CISMeF team)
- Dofetilide [ICD-11 Extension code]
See also inter- (CISMeF)
- Product containing dofetilide (medicinal product) [SNOMED CT concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Dofetilide (substance) [SNOMED CT concept]
- Product containing dofetilide (medicinal product) [SNOMED CT concept]
- dofetilide [ATC Code]
- dofetilide [MeSH concept]
- dofetilide [MeSH Supplementary Concept]
Validated automatic mappings to BTNT
- dofetilide [ATC Code]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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