Preferred Label : Diflunisal;
NCIt synonyms : 2',4'-Difluoro-4-hydroxy-(1,1'-biphenyl)-3-carboxylic Acid; (1,1'-Biphenyl)-3-carboxylic Acid, 2',4'-difluoro-4-hydroxy-;
NCIt definition : A difluorophenyl derivate of salicylic acid and a nonsteroidal anti-inflammatory drug
(NSAID) with antipyretic, analgesic and anti-inflammatory properties. Diflunisal competitively
inhibits both cyclooxygenase (COX) -1 and -2, with higher affinity for COX-1, and
subsequently blocks the conversion of arachidonic acid to prostaglandin precursors.
This leads to an inhibition of the formation of prostaglandins that are involved in
pain, inflammation and fever. Diflunisal differs from other salicylates, in that it
is not metabolized to salicylic acid, hence it has a longer half-life.;
UNII : 7C546U4DEN;
InChIKey : HUPFGZXOMWLGNK-UHFFFAOYSA-N;
CAS number : 22494-42-4;
Drug name : Apo-Diflunisal; Flovacil; Novo-Diflunisal; Nu-Diflunisal; Dolobid;
Chemical formula : C13H8F2O3;
ChEBI ID : CHEBI:39669;
Codes from synonyms : 20123;
Origin ID : C47489;
UMLS CUI : C0012228;
Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to BTNT
- concept_is_in_subset
