NCIt definition : A synthetic progestogen structurally related to levonorgestrel, with progesterone
hormone receptor agonistic activity, used as a contraceptive and hormone replacement
agent. Upon administration, desogestrel binds intracellular progesterone receptors
in progesterone responsive tissue and the resultant complex interacts with DNA causing
either gene transcription or gene repression. This eventually leads to an inhibition
of gonadotropin releasing hormone (GnRH) secretion from the hypothalamus and a subsequent
inhibition of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) release.
This prevents ovulation and alters the cervical mucus.;