NCIt definition : A synthetic recombinant form of the naturally occurring hirudin, the anticoagulant
substance found in leech. Desirudin is a selective and almost irreversible inhibitor
of thrombin, both free and clot-bound, by blocking its active site. This anticoagulant
agent has no effect on other components of the hemostatic system. Desirudin is particularly
used to prevent deep vein thrombosis in patients undergoing hip and knee replacement
surgery.;