Preferred Label : Dalfopristin;
NCIt synonyms : (3R,4R,5E,10E,12E,14S,26R,26aS)-26-((2-(Diethylamino)ethyl)sulfonyl)-8,9,14,15,24,25,26,26a-octahydro-14-hydroxy-3-isopropyl-4,12-dimethyl-3H-21,18-nitrilo-1H,22H-pyrrolo(2,1-c)(1,8,4,19)dioxadiazacyclotetracosine-1,7,16,22(4H,17H)-tetrone; Virginiamycin M1, 26-((2-(diethylamino)ethyl)sulfonyl)-26,27-dihydro-,(26R,27S)-;
NCIt definition : A semi-synthetic derivative of streptogramin A produced by streptomycetes. Dalfopristin
inhibits the early phase of protein synthesis in the bacterial ribosome by binding
to the 70S subunit, and also alters the configuration of the ribosome to make it more
susceptible for streptogramin B binding. Dalfopristin is used in combination with
quinopristin, a streptogramin B derivative. This combination is active against most
gram-positive organisms, including Enterococcus faecium, and is also active against
some gram-negative organisms and mycoplasma.;
UNII : R9M4FJE48E;
InChIKey : SUYRLXYYZQTJHF-VMBLUXKRSA-N;
CAS number : 112362-50-2;
Molecule name : RP 54476;
Chemical formula : C34H50N4O9S;
Origin ID : C47468;
UMLS CUI : C0756085;
Semantic type(s)
- concept_is_in_subset
- has_salt_form
- is_free_acid_or_base_form_of
