Preferred Label : Cycloserine;
NCIt synonyms : Tisomycin; Oxamycin; D-Cycloserine; ( )-4-Amino-3-isoxazolidinone; 3-Isoxazolidinone, 4-amino-, d-;
NCIt related terms : Seromycin;
NCIt definition : An analogue of the amino acid D-alanine with broad-spectrum antibiotic and glycinergic
activities. D-cycloserine interferes with bacterial cell wall synthesis by competitively
inhibiting two enzymes, L-alanine racemase and D-alanine:D-alanine ligase, thereby
impairing peptidoglycan formation necessary for bacterial cell wall synthesis. This
agent may be bactericidal or bacteriostatic, depending on its concentration at the
infection site and the susceptibility of the organism. In addition, D-cycloserine
is an excitatory amino acid and partial agonist at the glycine binding site of the
NMDA receptor in the central nervous system (CNS); binding to the central NMDA receptor
may result in amelioration of neuropathic pain.;
Alternative definition : NCI-GLOSS: A drug used to treat tuberculosis. It is also being studied in the treatment
of pain and nerve problems (numbness, tingling) caused by chemotherapy and in the
treatment of low back pain, autism, certain anxiety disorders, and schizophrenia.
D-cycloserine is a type of antibiotic.;
UNII : 95IK5KI84Z;
InChIKey : DYDCUQKUCUHJBH-UWTATZPHSA-N;
CAS number : 68-41-7;
Drug name : Seromycin;
Chemical formula : C3H6N2O2;
NSC code : 154851;
ChEBI ID : CHEBI:40009;
Codes from synonyms : CDR0000513053; CDR0000471784;
Origin ID : C47466;
UMLS CUI : C0010590;
Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to BTNT
- concept_is_in_subset
