" /> Cinacalcet Hydrochloride - CISMeF





Preferred Label : Cinacalcet Hydrochloride;

NCIt synonyms : 1-Naphthalenemethanamine, a-methyl-N-(3-(3-(trifluoromethyl)phenyl)propyl)-,(aR)-, Hydrochloride;

NCIt definition : The orally bioavailable hydrochloride salt of the calcimimetic cinacalcet. Cinacalcet increases the sensitivity of calcium-sensing receptors on chief cells in the parathyroid gland to extracellular calcium, thereby reducing parathyroid hormone (PTH) secretion. A reduction in PTH levels inhibits osteoclast activity, which may result in a decrease in cortical bone turnover and bone fibrosis, and normalization of serum calcium and phosphorus levels. In addition, by reducing PTH levels, cinacalcet may reduce PSA levels; PTH appears to raise PSA levels and may increase prostate cancer cell growth.;

UNII : 1K860WSG25;

InChIKey : QANQWUQOEJZMLL-PKLMIRHRSA-N;

CAS number : 364782-34-3; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 364782-34-3 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Drug name : Mimpara; Sensipar;

Chemical formula : C22H22F3N.HCl;

ChEBI ID : CHEBI:48391;

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16/05/2024


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