Preferred Label : Chlorthalidone;
NCIt synonyms : Chlorphthalidolone; Benzenesulfonamide, 2-Chloro-5-(2,3-dihydro-1-hydroxy-3-oxo-1H-isoindol-1-yl)-; Benzenesulfonamide, 2-chloro-5-(1-hydroxy-3-oxo-1-isoindolinyl)-;
NCIt definition : A long acting thiazide-like diuretic of the sulfamoylbenzamide class that is devoid
of the benzothiadiazine structure. Chlorthalidone directly inhibits sodium and chloride
reabsorption on the luminal membrane of the early segment in the distal convoluted
tubule (DCT) in the kidney. This leads to an increase in sodium, chloride, bicarbonate,
and potassium secretion resulting in the excretion of water. In addition, this agent,
like other thiazide diuretics, decreases calcium and uric acid secretion. In addition,
this agent inhibits many carbonic anhydrase (CA) isoenzymes. Chlorthalidone is used
in the treatment of high blood pressure, edema and congestive heart failure. The elimination
half-life is about 40 to 50 hours.;
UNII : Q0MQD1073Q;
InChIKey : JIVPVXMEBJLZRO-UHFFFAOYSA-N;
CAS number : 77-36-1;
Drug name : Hygroton; Thalitone;
Chemical formula : C14H11ClN2O4S;
NSC code : 69200;
ChEBI ID : CHEBI:3654;
Codes from synonyms : 01647;
Origin ID : C47449;
UMLS CUI : C0008294;
Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to BTNT
- concept_is_in_subset
