" /> Cefditoren Pivoxil - CISMeF





Preferred Label : Cefditoren Pivoxil;

NCIt synonyms : 5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic Acid, 7-(((2-amino-4-thiazolyl)(methoxyimino)acetyl)amino)-3-((1Z)-2-(4-methyl-5-thiazolyl)ethenyl)-8-oxo-,(2,2-dimethyl-1-oxopropoxy)methyl Ester,(6R,7R)-;

NCIt definition : A semi-synthetic, broad-spectrum, beta-lactamase resistant, third-generation cephalosporin antibiotic with bactericidal activity. Cefditoren pivoxil is a prodrug that is rapidly hydrolyzed by intestinal esterases during absorption to the microbiologically active cefditoren, an active aminothiazolyl cephalosporin. Cefditoren inactivates penicillin binding proteins (PBPs) thereby interfering with peptidoglycan synthesis and inhibiting bacterial cell wall synthesis. Another consequence of beta-lactam exposure results in the loss of lipoteichoic acids from the cell wall. Lipoteichoic acids inhibit murein hydrolase activity and their absence from the cell wall triggers uncontrolled autolytic activity rendering bacterial cells susceptible to osmotic shock. This results in a reduction of cell wall stability and causes cell lysis.;

UNII : 78THA212DH;

InChIKey : AFZFFLVORLEPPO-UVYJNCLZSA-N;

CAS number : 117467-28-4; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 117467-28-4 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Drug name : Spectracef;

Molecule name : ME 1207; CCRIS 7768;

Chemical formula : C25H28N6O7S3;

ChEBI ID : CHEBI:560555;

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16/06/2024


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