Preferred Label : Cefditoren Pivoxil;
NCIt synonyms : 5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic Acid, 7-(((2-amino-4-thiazolyl)(methoxyimino)acetyl)amino)-3-((1Z)-2-(4-methyl-5-thiazolyl)ethenyl)-8-oxo-,(2,2-dimethyl-1-oxopropoxy)methyl
Ester,(6R,7R)-;
NCIt definition : A semi-synthetic, broad-spectrum, beta-lactamase resistant, third-generation cephalosporin
antibiotic with bactericidal activity. Cefditoren pivoxil is a prodrug that is rapidly
hydrolyzed by intestinal esterases during absorption to the microbiologically active
cefditoren, an active aminothiazolyl cephalosporin. Cefditoren inactivates penicillin
binding proteins (PBPs) thereby interfering with peptidoglycan synthesis and inhibiting
bacterial cell wall synthesis. Another consequence of beta-lactam exposure results
in the loss of lipoteichoic acids from the cell wall. Lipoteichoic acids inhibit murein
hydrolase activity and their absence from the cell wall triggers uncontrolled autolytic
activity rendering bacterial cells susceptible to osmotic shock. This results in a
reduction of cell wall stability and causes cell lysis.;
UNII : 78THA212DH;
InChIKey : AFZFFLVORLEPPO-UVYJNCLZSA-N;
CAS number : 117467-28-4;
Drug name : Spectracef;
Molecule name : ME 1207; CCRIS 7768;
Chemical formula : C25H28N6O7S3;
ChEBI ID : CHEBI:560555;
Origin ID : C47434;
UMLS CUI : C0245519;
Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
