Preferred Label : Carboprost Tromethamine;
NCIt synonyms : (15S)-15-Methylprostaglandin F(sub 2alpha) Tromethamine; Prosta-5,13-dien-1-oic acid, 9,11,15-trihydroxy-15-methyl-,(5Z,9-alpha,11-alpha,13E,15S)-,
compound with 2-Amino-2-(hydroxymethyl)-1,3-propanediol(1:1); (15S)-9a, 11a, 15-Trihydroxy-15-methyl-prosta-cis-5, trans-13-dienoic Acid Tromethamine
Salt;
NCIt definition : The tromethamine salt of the (15S)-15 methyl analogue of naturally occurring prostaglandin
F2 alpha (PGF2 alpha) with oxytocic activity. Mimicking endogenous PGF2 alpha, carboprost
activates prostaglandin F receptor, a G-protein coupled receptor, on smooth muscle
cells, thereby resulting in smooth muscle contractions. When administered intramuscularly
on gravid subjects, this agent induces myometrium contractions, thereby initiating
luteolysis and consequently parturition. Furthermore, carboprost's action on vascular
smooth muscle and gastrointestinal tract sphincters leads to raised blood pressure
and induces vomiting or diarrhea, respectively.;
UNII : U4526F86FJ;
InChIKey : UMMADZJLZAPZAW-XOWPVRJPSA-N;
CAS number : 58551-69-2;
Drug name : Hemabate;
Chemical formula : C21H36O5.C4H11NO3;
ChEBI ID : CHEBI:3404;
Origin ID : C47433;
UMLS CUI : C0054721;
CISMeF manual mappings
- Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
- has_free_acid_or_base_form
- is_salt_form_of
