NCIt definition : A synthetic ergoline derivative and a long-acting dopamine receptor agonist with high
affinity for the dopamine D2 receptor. Cabergoline exerts an inhibitory effect on
prolactin secretion by acting on dopamine receptors present in pituitary lactotrophs.
This drug also binds to dopamine D2 receptors in the corpus striatum, thereby mimicking
the actions of dopamine on motor control. Cabergoline also possesses antioxidant and
neuroprotective properties due to its free radical scavenging activity. Cabergoline
is used in the treatment of Parkinson's disease and in the treatment of hyperprolactinemia.;