Preferred Label : Butenafine Hydrochloride;
NCIt synonyms : N-((4-(1,1-Dimethylethyl)phenyl)methyl)-N-methyl-1-naphthalenemethanamine Hydrochloride; N-4-tert-Butylbenzyl-N-methyl-1-naphthalenemethylamine Hydrochloride;
NCIt definition : The hydrochloride salt form of butenafine, a synthetic benzylamine derivative with
fungicidal properties. Butenafine hydrochloride interferes with the biosynthesis of
ergosterol, an important component of fungal cell membranes, by inhibiting the epoxidation
of squalene. This alters fungal membrane permeability and causes growth inhibition.
Butenafine hydrochloride is active against a number of dermatophytes, including Trichophyton
rubrum, Trichophyton mentagrophytes, Microsporum canis, Sporothrix schenckii, and
yeasts, including Candida albicans and C. parapsilosis.;
UNII : R8XA2029ZI;
InChIKey : LJBSAUIFGPSHCN-UHFFFAOYSA-N;
CAS number : 101827-46-7;
Drug name : Mentax; Lotrimin Ultra;
Molecule name : KP-363;
Chemical formula : C23H27N.HCl;
ChEBI ID : CHEBI:31325;
Origin ID : C47426;
UMLS CUI : C0771847;
Automatic exact mappings (from CISMeF team)
- CISMeF manual mappings
- Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
- has_free_acid_or_base_form
- is_salt_form_of
