Preferred Label : Buprenorphine Hydrochloride;
NCIt synonyms : Subutex; (5alpha,7alpha(S))-alpha-tert-Butyl-17-(cyclopropylmethyl)-4,5-epoxy-18,19-dihydro-3-hydroxy-6-methoxy-alpha-methyl-6,14-ethenomorphinan-7-methanol
Hydrochloride;
NCIt definition : The hydrochloride salt form of buprenorphine, a synthetic phenanthrene with narcotic
analgesic activity. Buprenorphine hydrochloride is a partial agonist at the mu-opioid
receptor and an antagonist at the kapa-opioid receptor in the central nervous system.
However, under the conditions of recommended use it behaves as a classic mu-opioid
agonist, mimicking the actions of endogenous peptides at CNS opioid receptors. The
agonist action results in a raised pain threshold and increased tolerance to pain.
However, it also causes sedation, physical dependence, and respiratory depressant
effects and decreases heart rate and blood pressure.;
UNII : 56W8MW3EN1;
InChIKey : UAIXRPCCYXNJMQ-RZIPZOSSSA-N;
CAS number : 53152-21-9;
Drug name : Buprenex;
Molecule name : RX 6029-M HCl; NIH 8805;
Chemical formula : C29H41NO4.HCl;
ChEBI ID : CHEBI:652822;
Origin ID : C47424;
UMLS CUI : C0701445;
Automatic exact mappings (from CISMeF team)
- Currated CISMeF NLP mapping
- Semantic type(s)
- Validated automatic mappings to NTBT
- concept_is_in_subset
- has_free_acid_or_base_form
- is_salt_form_of
