NCIt definition : A sulfonamide and carbonic anhydrase inhibitor with specific affinity for carbonic
anhydrase II. Following topical ocular administration, brinzolamide inhibits carbonic
anhydrase II, an enzyme that is responsible for the movement of sodium and fluid transport
in the eye. This inhibition leads to a decrease in aqueous humor secretion, probably
by slowing the formation of bicarbonate ions, and results in a reduction in intraocular
pressure. Brinzolamide is used to treat increased pressure in the eye caused by open-angle
glaucoma.;