" /> Bretylium Tosylate - CISMeF





Preferred Label : Bretylium Tosylate;

NCIt synonyms : Darentin; (o-Bromobenzyl)ethyldimethylammonium p-Toluenesulfonate; 2-Bromo-N-ethyl-N,N-dimethylbenzenemethanaminium 4-Methylbenzenesulfonate;

NCIt definition : The tosylate salt form of bretylium, a quaternary ammonium salt and non-selective adrenergic neuronal blocking agent with anti-arrhythmic properties. Bretylium tosylate is selectively taken up into peripheral nerve terminals and initially causes a release of norepinephrine from sympathetic nerve endings, thereby causing a sympathomimetic effect. This is followed by a prolonged anti-adrenergic action which prevents further discharge of neurotransmitter from sympathetic nerve endings. Its myocardial effects include a prolongation of action potential as well as refractory period. This drug is used to treat and suppress ventricular arrhythmias, particularly ventricular fibrillation and ventricular tachycardia.;

UNII : 78ZP3YR353;

InChIKey : KVWNWTZZBKCOPM-UHFFFAOYSA-M;

CAS number : 61-75-6;

Drug name : Bretylol;

Chemical formula : C11H17BrN.C7H7O3S;

NSC code : 62164;

ChEBI ID : CHEBI:3173;

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08/05/2025


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