" /> Azelaic Acid - CISMeF





Preferred Label : Azelaic Acid;

NCIt synonyms : Heptanedicarboxylic Acid; Lepargylic Acid; 1,9-Nonanedioic Acid;

NCIt definition : A naturally occurring dicarboxylic acid produced by Malassezia furfur and found in whole grain cereals, rye, barley and animal products. Azelaic acid possesses antibacterial, keratolytic, comedolytic, and anti-oxidant activity. Azelaic acid is bactericidal against Proprionibacterium acnes and Staphylococcus epidermidis due to its inhibitory effect on the synthesis of microbial cellular proteins. Azelaic acid exerts its keratolytic and comedolytic effects by reducing the thickness of the stratum corneum and decreasing the number of keratohyalin granules by reducing the amount and distribution of filaggrin in epidermal layers. Azelaic acid also possesses a direct anti-inflammatory effect due to its scavenger activity of free oxygen radical. This drug is used topically to reduce inflammation associated with acne and rosacea.;

UNII : F2VW3D43YT;

InChIKey : BDJRBEYXGGNYIS-UHFFFAOYSA-N;

CAS number : 123-99-9; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 123-99-9 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Drug name : Finacea; Azelex;

Molecule name : ZK 62498;

Chemical formula : C9H16O4;

NSC code : 19493;

ChEBI ID : CHEBI:48131;

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26/05/2024


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