Preferred Label : Apomorphine Hydrochloride;
NCIt synonyms : N-Methylnorapomorphine Hydrochloride; 4H-Dibenzo(de,g)quinoline-10,11-diol, 5,6,6a,7-Tetrahydro-6-methyl-, Hydrochloride,(6aR)-; 6ab-Aporphine-10,11-diol Hydrochloride Hemihydrate;
NCIt definition : The hydrochloride salt form of apomorphine, a derivative of morphine and non-ergoline
dopamine agonist with high selectivity for dopamine D2, D3, D4 and D5 receptors. Apomorphine
hydrochloride acts by stimulating dopamine receptors in the nigrostriatal system,
hypothalamus, limbic system, pituitary gland, and blood vessels. This enhances motor
function, suppresses prolactin release, and causes vasodilation and behavioral effects.
Apomorphine hydrochloride is used in the treatment of Parkinson's disease and erectile
dysfunction. In addition, apomorphine hydrochloride acts on the chemoreceptor trigger
zone and is used as a central emetic in the treatment of drug overdose.;
UNII : F39049Y068;
InChIKey : CXWQXGNFZLHLHQ-DPFCLETOSA-N;
CAS number : 41372-20-7;
Drug name : Apokyn; Uprima;
Chemical formula : 2C17H17NO2.2ClH.H2O;
NSC code : 11442;
ChEBI ID : CHEBI:31228;
Origin ID : C47400;
UMLS CUI : C0237406;
Automatic exact mappings (from CISMeF team)
- Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to NTBT
- concept_is_in_subset
- has_free_acid_or_base_form
- is_salt_form_of
