NCIt definition : A synthetic indanedione anticoagulant. Anisindione interferes with the vitamin K-dependent
hepatic synthesis of active clotting factors by inhibiting the reduction of vitamin
K. This leads to an inhibition of gamma-carboxylation of glutamic acid residues to
gamma-carboxyglutamic acid in clotting factors II, VII, IX and X. The consequential
effects of this inhibition include a reduced activity of these clotting factors and
prolonged blood clotting time.;