NCIt definition : A synthetic lysine derivative with antifibrinolytic activity. Aminocaproic acid competitively
inhibits activation of plasminogen, thereby reducing conversion of plasminogen to
plasmin (fibrinolysin), an enzyme that degrades fibrin clots as well as fibrinogen
and other plasma proteins including the procoagulant factors V and VIII. Aminocaproic
acid competitively reduces the conversion of plasminogen to plasmin by plasminogen
activators. It directly inhibits proteolytic activity of plasmin, but higher doses
are required than are needed to reduce plasmin formation. Aminocaproic acid is used
in the treatment of hemorrhage and prophylactically against hemorrhage, including
hyperfibrinolysis-induced hemorrhage and postsurgical hemorrhage.;