NCIt definition : A butyrophenone with anti-emetic, sedative and anti-anxiety properties. Although the
exact mechanism through which droperidol exerts its effects is unknown, droperidol
may block dopamine receptors in the chemoreceptor trigger zone (CTZ), which may lead
to its anti-emetic effect. This agent may also bind to postsynaptic gamma-aminobutyric
acid (GABA) receptors in the central nervous system (CNS), which increases the inhibitory
effect of GABA and leads to sedative and anti-anxiety activities.;
Alternative definition : NCI-GLOSS: A drug used to prevent nausea and vomiting in patients who receive anesthesia
before surgery. It is also used to treat anxiety. Droperidol is a type of antiemetic,
adjunct anesthesia, and antipsychotic.;