Mediastinal T Lymphoblastic Lymphoma

Preferred Label : Mediastinal T Lymphoblastic Lymphoma;

NCIt synonyms : Primary Mediastinal Precursor T-Lymphoblastic Lymphoma; Mediastinal Precursor T-Lymphoblastic Lymphoma; Mediastinal T-Lymphoblastic Lymphoma;

NCIt definition : A precursor T lymphoblastic lymphoma that arises from the mediastinum. It usually presents with an anterior mediastinal mass and respiratory distress. It may present acutely with superior vena cava syndrome. It usually affects adolescent and young adult males. It is treated with aggressive chemotherapy and radiation. The prognosis is better in the pediatric patients.;

Neoplastic status : Malignant;

Details

Origin ID

C45740;

UMLS CUI

C1708958;

Disease excludes abnormal cell
- Lymphocyte Predominant Cell [NCIt concept]
- Neoplastic B-Lymphocyte [NCIt concept]
- Reed-Sternberg Cell [NCIt concept]
Disease excludes normal cell origin
- Myeloid Cell [NCIt concept]
- Peripheral (Post-Thymic) T-Lymphocyte [NCIt concept]
- Plasma Cell [NCIt concept]
Disease may have findings
- Aggressive Clinical Course [NCIt concept]
- Hepatomegaly [NCIt concept]
- High Mitotic Activity [NCIt concept]
- Lymphadenopathy [NCIt concept]
- Lymphoblasts 25 Percent or Less of Bone Marrow Nucleated Cells [NCIt concept]
- Malignant Pleural Effusion [NCIt concept]
- Skin Nodule [NCIt concept]
- Starry Sky Pattern [NCIt concept]
Excludes anatomical site(s)
- Neck [NCIt concept]
Has associated anatomic sites
- Hematopoietic System [NCIt concept]
- Hematopoietic and Lymphatic System [NCIt concept]
- Mediastinum [NCIt concept]
- Respiratory System [NCIt concept]
- Thoracic Cavity [NCIt concept]
Semantic type(s)
- Neoplastic Process [UMLS semantic type]
disease_excludes_finding
- Benign Cellular Infiltrate [NCIt concept]
disease_has_abnormal_cell
- Abnormal Lymphocyte [NCIt concept]
- Malignant Cell [NCIt concept]
- Neoplastic Cell [NCIt concept]
- Neoplastic Hematopoietic and Lymphoid Cell [NCIt concept]
- Neoplastic Lymphoblast [NCIt concept]
- Neoplastic Lymphocyte [NCIt concept]
- Neoplastic T-Lymphoblast [NCIt concept]
- Neoplastic T-Lymphocyte and Neoplastic Natural Killer Cell [NCIt concept]
disease_has_finding
- Malignant Cellular Infiltrate [NCIt concept]
- Mediastinal Mass [NCIt concept]
disease_has_normal_cell_origin
- Hematopoietic and Lymphoid Cell [NCIt concept]
- Lymphoblast [NCIt concept]
- Lymphocyte [NCIt concept]
- Precursor T-Lymphoblast [NCIt concept]
- T-Lymphocyte and Natural Killer Cell [NCIt concept]
disease_has_normal_tissue_origin
- Hematopoietic and Lymphoid Tissue [NCIt concept]
- Lymphoid Tissue [NCIt concept]
disease_has_primary_anatomic_site
- Hematopoietic and Lymphatic System [NCIt concept]
- Lymphatic System [NCIt concept]
- Mediastinum [NCIt concept]
disease_mapped_to_gene
- NOTCH1 Gene [NCIt concept]
disease_may_have_cytogenetic_abnormality
- del(9p21p22) [NCIt concept]
- inv(14)(q11;q32.1) [NCIt concept]
- t(10;14)(q24;q11) [NCIt concept]
- t(11;14)(p13;q11) [NCIt concept]
- t(11;14)(p15;q11) [NCIt concept]
- t(14;14)(q11;q32) [NCIt concept]
- t(1;14)(p32;q11) [NCIt concept]
- t(1;7)(p33;q35) [NCIt concept]
- t(7;10)(q34;q24) [NCIt concept]
- t(7;14)(q35;q32.1) [NCIt concept]
- t(7;19)(q34;q13) [NCIt concept]
- t(7;9)(q34;q32) [NCIt concept]
- t(7;9)(q34;q34.3) [NCIt concept]
- t(8;13)(p11;q11) [NCIt concept]
disease_may_have_molecular_abnormality
- Clonal T-Cell Receptor Beta Chain Gene Rearrangement [NCIt concept]
- Clonal T-Cell Receptor Gamma Chain Gene Rearrangement [NCIt concept]
- NOTCH1 Gene Mutation [NCIt concept]

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