Preferred Label : Oncogene MCF2;
Obsolete resource : true;
NCIt synonyms : MCF.2 Cell Line Derived Transforming Sequence; DBL; Diffuse B-Cell Lymphoma Oncogene; MCF2;
NCIt definition : Human Oncogene MCF2 is a mutated variant of widely expressed MCF2 Gene, which encodes
4 alternative variants of 66-kDa MCF2 (DBL) p66 Protein, a cytoplasmic and membrane
phosphoserine guanine nucleotide exchange factor that modulates the activity of small
RHO GTPases by promoting conversion from GDP- to GTP-bound form. p66 contains a CRAL-TRIO
domain, a DH domain, a PH domain and a spectrin repeat; the DH domain catalyzes GDP-GTP
exchange. Five-prime recombinations of MCF2 delete N-terminal codons, producing activated
oncogenic variant; the upstream replacing sequence, URS, is derived from D15S93 at
15q15-q23. Oncogene MCF2 disrupts normal cell function.;
NCIt note : See 'Oncogene DBL';
Concept status : Retired_Concept;
GenBank Accession Number : NM_005369;
Origin ID : C45491;
UMLS CUI : C1705243;
OMIM relation
- Semantic type(s)
