Collagenous Sprue

Preferred Label : Collagenous Sprue;

NCIt definition : A rare disorder affecting the digestive tract. Its cause is unclear but may be attributed, in part, to increased collagen synthesis without adequate fibrolysis. It is characterized histologically by atrophy of mucosal villi and crypts with extensive subepithelial collagen deposition. Clinical signs include nausea, vomiting, diarrhea and weight loss. Unlike celiac sprue (celiac disease), a gluten-free diet does not predict a certain regression of the disease. The clinical course follows a progression of malabsorption leading to nutritional deficiencies, small bowel ulceration/perforation, lymphoma and infection. Prognosis is usually dismal.;

Details

Origin ID

C45426;

UMLS CUI

C0341299;

Automatic exact mappings (from CISMeF team)
- Collagenous sprue [ICD-11 More detail]
- Non-gluten sensitive enteropathy syndrome (disorder) [SNOMED CT concept]
- collagenous sprue [MeSH Descriptor]
- collagenous sprue [MeSH concept]
Has associated anatomic sites
- Digestive System [NCIt concept]
- Intestine [NCIt concept]
Semantic type(s)
- Disease or Syndrome [UMLS semantic type]
UMLS correspondences (same concept)
- Non-gluten sensitive enteropathy syndrome (disorder) [SNOMED CT concept]
- collagenous sprue [MeSH concept]
- collagenous sprue [MeSH Descriptor]
- non-gluten sensitive enteropathy syndrome [SNOMED Notion]
disease_has_primary_anatomic_site
- Digestive System [NCIt concept]

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